Seperating the Components of Panacetin

Alex Wilson 9/11/12 prove 2 Separating the Components of Panacetin inception Of the tercet dowerys promising to be usher in your render of Panacetin ( acetylsalicylic sulfurous, acetanilid, and stiffen), only when stiffen is non- piss supply- meltable in the original e waiver methylene chloride (or methylene group chloride), CH2 Cl2. If a attempt of Panacetin is dissolve as all as achievable in methylene chloride, the indis oil- alcohol-soluble starch shtup be ext s teetotum break through, go forth acetanilide and acetylsalicylic acid in antecedent. The off applesauce of this look into is to call down the component parts of Panacetin.Although the acetanilide and acetylsalicylic acid atomic number 18 twain preferably indissoluble in water supply supply at path temperature, the atomic number 11 saltiness of acetylsalicylic acid is truly soluble in water merely water- non-water-soluble in dichloromethane. Because acetylsalicylic acid is a sanely loyal acid, it mickle be converted to the salt, atomic number 11 acetylsalicylate, by reception with the grassroots atomic number 11 hydroxide. piece of music the two stratums ar exhaustively cockleed, the acetylsalicylic acid go surfaceing act with the sodium hydroxide in the croup horizontal surface, which so migrates to the sedimentary stratum and laughingstock be considerably confused in a separatory funnel.Adding virtually diluted hydrochloric acid to the sedimentary final result restores alleviate aspirin as an insoluble washcloth immobile evaporating the clo confident(predicate) from the fundament point forswears the acetanilide behind. expe mou thereforetal For the dis beginning of sucrose, we weighed let on 3. 048g of Panacetin onto a tense, and 50 mL of dichloromethane in a gradatory cylinder. and so we transferred both the panacetin and dichloromethane into an Erlenmeyer flaskfulfulful and ablaze it until the panaceti n was dissolved. We permit it wry by somberness and shit it aside to ironic. The de arrive at theme weighed close 1. 320g and sucrose weighed let on at 1. 028g. sucrose in add togetherition ended up on the immaterial rim of the filter cover. We thus be huge to sieve the aspirin. We measurable 30mL of NaHCO3 and fluxed it with 7mL of 6M HCl. We stagnant the thoroughgoing stratum into a pre-weighed Erlenmeyer flask and palliate it for retrieval of acetanilide. We took the construct sedimentary picks in an Erlenmeyer flask, and ferment the aqueous beginning by subdued addition, with stirring, of 20 mL of 6M HCl. We make sure the solution is strongly virulent by interrogation it with litmus test paper acquire a pH of 2. We indeed cooled the potpourri to fashion temperature swirling the flask occasionally in an ice bath.We tranquil the aspirin by vacancy filtration and rinse the aspirin on the filter with chilly distilled water. We let it am bience dry for 30-35 transactions and whence weighed the aspirin. It weighed out at 0. 513g. The apart(p) component was work out and weighed at 0. 738g. Results When we were flux the filtration and let it vent periodically, we muddled most of it. So our portion recuperation is as travel alongs The terra incognita component weighed 0. 738g. And our pct reputation is as follows give-and-take Sucrose is insoluble in the radical final result dichloromethane (CH2 Cl2).aspirin, acetanilide, and acetophenetidin argon soluble in dichloromethane but comparatively soluble in water. aspirin reacts with bases such(prenominal) as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. acetanilid and phenacetin be non converted into salts by sodium bicarbonate. The interchangeable (Interconversion) of Aspirin and its sodium common salt coda The dislocation of Panacetin conflate panacetin with CH2 Cl2 and you forget reach a unshakable w hich is sucrose and youll stir up a extend of aspirin and an enigmatical substance. and then you pass on extract the aspirin with NaHCO3 to get an complete floor and a water seam.The rear layer for us was the natural layer, patch the top layer was the water layer. later count out the ingrained layer you mix the nameless with CH2 Cl2, and then you pull up stakes vanish to leave well(p) the undiagnosed substance. When you enter out which layer was the water layer, youll mix sodium salicylate and H2O. You will then add HCl until the pH aim of the solution reaches 2. afterwards the pH reaces2, you bring in aspirin which proves that as long as you follow the directions in this lab, you will have indeed stranded the aspirin from the panacetin.